Therapies for Raising High-density Lipoprotein Cholesterol

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Therapies for raising high-density lipoprotein cholesterol.

A low high-density lipoprotein cholesterol (HDL-C) level is one of the strongest predictors of coronary risk (1). The negative correlation between coronary artery disease (CAD) and plasma HDL-C has been attributed to the ability of HDL to take up cellular cholesterol from the periphery and to mediate the transport of excess cholesterol to the liver (reverse cholesterol transport, RCT) (2). In J...

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High-density lipoprotein metabolism and reverse cholesterol transport: strategies for raising HDL cholesterol

A key to effective treatment of cardiovascular disease is to understand the body's complex lipoprotein transport system. Reverse cholesterol transport (RCT) is the process of cholesterol movement from the extrahepatic tissues back to the liver. Lipoproteins containing apoA-I [highdensity lipoprotein (HDL)] are key mediators in RCT, whereas non-high-density lipoproteins (non-HDL, lipoproteins co...

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ژورنال

عنوان ژورنال: Internal Medicine

سال: 2007

ISSN: 0918-2918,1349-7235

DOI: 10.2169/internalmedicine.46.6206